FB2026_02 , released June 18, 2026
Allele: Dmel\AcerRNAi.UAS
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General Information
Symbol
Dmel\AcerRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0295868
Feature type
allele
Associated gene
Dmel\Acer
Associated Insertion(s)
Carried in Construct
P{UAS-Acer.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Liao et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Liao et al., 2014)
Mutagen
in vitro construct
(Liao et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-Acer.RNAi}
Cytology
Description

UAS regulatory sequences drive expression of an inverted 523bp fragment of Acer cDNA (LD28328).

(Liao et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Acer
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing AcerdsRNA.Scer\UAS under the control of mesodermal- and cardial-specific Scer\GAL4twi.PG and Scer\GAL4how-24B exhibit significantly enlarged diastolic and systolic chamber dimensions with markedly impaired systolic function. These flies also exhibit a steep age-related decline in heart rate, with a heart rate consistently slower than in wild-type. Down-regulation of Acer impairs the contractile properties of the heart.

      Down-regulation of Acer, through expression of AcerdsRNA.Scer\UAS under the control of Scer\GAL4twi.PG and Scer\GAL4how-24B increases the likelihood of heart failure.

      (Liao et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      AcerRNAi.UAS
      AcerdsRNA.Scer\UAS
      AcerdsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)