FB2026_02 , released June 18, 2026
Allele: Dmel\cal12k32
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General Information
Symbol
Dmel\cal12k32
Species
D. melanogaster
Name
FlyBase ID
FBal0295899
Feature type
allele
Associated gene
Dmel\cal1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Unhavaithaya et al., 2013)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q930term.

(Unhavaithaya et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:17,091,249..17,091,249 [+]
Nucleotide change:

C17091249T

Amino acid change:

Q931term | cal1-PA

Reported amino acid change:

Q930term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Unhavaithaya et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous females show significantly increased X and 4th chromosome nondisjunction compared to wild-type controls. The nondisjunction events occur in meiosis I.

      (Unhavaithaya and Orr-Weaver, 2013)

      Isolated cells in the central nervous system have increased nuclear size and ploidy in homozygous embryos.

      (Unhavaithaya et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      cal12k32 has abnormal meiotic cell cycle | semidominant phenotype, enhanceable by Cenp-C[+]/Cenp-CIR35

      (Unhavaithaya and Orr-Weaver, 2013)
      Enhancer of
      Statement
      Reference

      cal12k32/cal1[+] is an enhancer of abnormal meiotic cell cycle | semidominant phenotype of Cenp-CIR35

      (Unhavaithaya and Orr-Weaver, 2013)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      cal12k32/Df(3R)Exel6149 double heterozygous females do not show a significant increase in X chromosome non disjunction compared to wild-type controls.

      (Unhavaithaya and Orr-Weaver, 2013)

      cal12k32/Cenp-CIR35, cal12k32/Df(3R)Exel6149 and cal12k32/Cenp-CZ3-4375 double heterozygous females show defects in centromere clustering in the oocyte, with defects being evident by region 3 of the germarium. Defects in centromere pairing are also seen.

      The centromeres are separated from the nucleolus in the oocytes of double heterozygous cal12k32/Cenp-CIR35 females (in contrast to wild type where they are adjacent).

      cal12k32/Cenp-CIR35 double heterozygous females show significantly increased X and 4th chromosome nondisjunction compared to wild-type controls, with the frequency of nondisjunction being increased compared to the phenotypes seen in single heterozygotes.

      (Unhavaithaya and Orr-Weaver, 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      cal12K32
      (Hatkevich et al., 2019)
      cal12k32
      (Unhavaithaya and Orr-Weaver, 2013, Unhavaithaya and Orr-Weaver, 2013, Unhavaithaya et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)