FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Cenp-CZ3-4375
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General Information
Symbol
Dmel\Cenp-CZ3-4375
Species
D. melanogaster
Name
FlyBase ID
FBal0296083
Feature type
allele
Associated gene
Dmel\Cenp-C
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Unhavaithaya and Orr-Weaver, 2013)
Mutagen
ethyl methanesulfonate
(Unhavaithaya and Orr-Weaver, 2013)
Progenitor genotype
Cytology
Description

Amino acid replacement: P1115S.

(Unhavaithaya and Orr-Weaver, 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:8,567,865..8,567,865 [+]
Nucleotide change:

C8567865T

Amino acid change:

P1116S | Cenp-C-PA; P1104S | Cenp-C-PB

Reported amino acid change:

P1115S

Comment:

Reported as a P1115S mutation relative to Cenp-C-PA. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Unhavaithaya and Orr-Weaver, 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Cenp-CZ3-4375/Cenp-CIR35 females show defects in centromere clustering in the oocyte, with a failure of clustering being evident by pachytene in region 3 of the germarium (centromere clustering at the earlier zygotene stage is normal). Defects in clustering are also seen in the oocytes of homozygous Cenp-CZ3-4375 females, although they are not as pronounced as those seen in the transheterozygous Cenp-CZ3-4375/Cenp-CIR35 females. Defects in centromere pairing are also seen, in the oocytes of both homozygous Cenp-CZ3-4375 and transheterozygous Cenp-CZ3-4375/Cenp-CIR35 females.

      The centromeres are separated from the nucleolus in the oocytes of Cenp-CZ3-4375/Cenp-CIR35 females (in contrast to wild type where they are adjacent).

      (Unhavaithaya and Orr-Weaver, 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      cal12k32/Cenp-CZ3-4375 double heterozygous females show defects in centromere clustering in the oocyte, with defects being evident by region 3 of the germarium. Defects in centromere pairing are also seen.

      (Unhavaithaya and Orr-Weaver, 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Cenp-CIR35/Cenp-CZ3-4375 is rescued by Cenp-CEYFP

      (Unhavaithaya and Orr-Weaver, 2013)
      Comments

      Cenp-CT:Avic\GFP-EYFP restores normal centromere clustering in the oocytes of Cenp-CZ3-4375/Cenp-CIR35 females.

      (Unhavaithaya and Orr-Weaver, 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Cenp-CZ3-4375
      (Fellmeth et al., 2023)
      cenp-CZ3-4375
      (Unhavaithaya and Orr-Weaver, 2013, Unhavaithaya and Orr-Weaver, 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)