FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Fen1EY12786
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General Information
Symbol
Dmel\Fen1EY12786
Species
D. melanogaster
Name
FlyBase ID
FBal0295952
Feature type
allele
Associated gene
Dmel\Fen1
Associated Insertion(s)
P{EPgy2}Fen1EY12786
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{EPgy2}Fen1EY12786
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{EPgy2}
    Regulatory region(s)
    UASp
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Severe neuroblast loss is seen in the brains of Fen1EY12786 mutant larvae. Many of the remaining neuroblasts exhibit necrosis markers, including aggregation of mitochondria, elevated levels of calcium ions and the presence of ubiquitin-conjugated protein aggregates.

        (Kuang et al., 2014)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Suppressed by
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Expression of fzyScer\UAS.cKa under the control of Scer\GAL4wor.PA partially suppresses the neuroblast loss seen in Fen1EY12786 mutant larval brains. However, these surviving neuroblasts display phenotypes indicative of mitotic catastrophe including multinucleation and enlargement of cell diameter.

        p535A-1-4/p5311-1B-1 partially suppresses the neuroblast loss seen in Fen1EY12786 mutant larval brains.

        (Kuang et al., 2014)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Fen1EY12786
        Name Synonyms
        Secondary FlyBase IDs
          References (1)