FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\RPS15T136A.UAS
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General Information
Symbol
Hsap\RPS15T136A.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0296070
Feature type
allele
Associated gene
Hsap\RPS15
Associated Insertion(s)
Carried in Construct
P{UAS-hRPS15.T136A}
Key Links
Transgenic product class
missense_variant
(Martin et al., 2014)
polypeptide_post_translational_processing_variant
(Martin et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Martin et al., 2014)
polypeptide_post_translational_processing_variant
(Martin et al., 2014)
Mutagen
in vitro construct
(Martin et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-hRPS15.T136A}
Cytology
Description

UASt regulates expression of full-length Hsap\RPS15 cDNA containing a T136A substitution which significantly reduces Hsap\LRRK2-mediated phosphorylation of the protein.

(Martin et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\RPS15
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The dopamine neuron degeneration and locomotor dysfunction observed in aged flies expressing Hsap\LRRK2G2019S.Scer\UAS.T:Zzzz\FLAG via Scer\GAL4Ddc.PL are completely rescued by co-expression of Hsap\RPS15T136A.Scer\UAS.

      (Martin et al., 2014)

      Co-expression of Hsap\RPS15T136A.Scer\UAS prevents the neuro-degenerative phenotype seen in flies expressing Hsap\LRRK2G2019S.Scer\UAS.cLa.T:Zzzz\FLAG under the control of Scer\GAL4Ddc.PL.

      (Martin et al., 2014)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\RPS15T136A.Scer\UAS
      Hsap\RPS15T136A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)