FB2026_02 , released June 18, 2026
Allele: Dmel\LhrKO
Open Close
General Information
Symbol
Dmel\LhrKO
Species
D. melanogaster
Name
FlyBase ID
FBal0296130
Feature type
allele
Associated gene
Dmel\Lhr
Associated Insertion(s)
TI{TI}LhrKO
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Satyaki et al., 2014)
Mutagen
ends-out gene targeting
(Satyaki et al., 2014)
Progenitor genotype
Associated Insertion(s)
TI{TI}LhrKO
Cytology
Description

26bp of the Lhr coding region has been replaced by a w+mW.hs marker.

(Satyaki et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      LhrKO flies are almost fully viable (22.25% homozygotes are recovered compared to the expected 25% in crosses between heterozygotes).

      Homozygous LhrKO females have significantly reduced fertility, particularly at higher temperatures. At 27[o]C, 1-5 old homozygotes have severely reduced fertility (assayed by mean number of progeny per female) and they later become sterile. The hatching rate of eggs laid by homozygous females is low and declines as the females age.

      LhrKO/Df(2R)BSC44 females have normal fertility at 1-5 days of age at 27[o]C, but have severely reduced fertility at 6-9 days of age, with the fertility declining even further in older females.

      Crosses of homozygous LhrKO D. melanogaster females crossed to D. mauritiana males at 18[o]C give rise to 10.6% rescue of live hybrid males.

      (Satyaki et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      LhrKO
      (Satyaki et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)