FlyBase Allele Report: Dmel\mael[sat]

General Information

Symbol

Dmel\mael^sat

Species

D. melanogaster

Name

FlyBase ID

FBal0296232

Feature type

allele

Associated gene

Dmel\mael

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Hayashi et al., 2014)

Progenitor genotype

Cytology

Description

Amino acid replacement: E131R.

(Hayashi et al., 2014)

Nucleotide substitution: G?A.

(Hayashi et al., 2014)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:22,725,066..22,725,066 [+]

Nucleotide change:

G22725066A

Reported nucleotide change:

G?A

Amino acid change:

E131K | mael-PA; E131K | mael-PB; E134K | mael-PC; E131K | mael-PD

Reported amino acid change:

E131R

Comment:

Reported as a GAG to AAG codon change, which is E to K rather than E to R as reported. Mutant strain also has a splice acceptor mutation in Klc.

(Hayashi et al., 2014)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

dorsal appendage | germline clone | maternal effect

(Hayashi et al., 2014)

Detailed Description

Statement

Reference

Females carrying homozygous germline clones lay many eggs that have reduced or fused dorsal appendages, and a few eggs have no dorsal appendages.

(Hayashi et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

mael^sat has dorsal appendage | maternal effect | germline clone phenotype, enhanceable | germline clone by Klc^sat

(Hayashi et al., 2014)

Enhancer of

Statement

Reference

mael^sat is an enhancer | germline clone of dorsal appendage | maternal effect | germline clone phenotype of Klc^sat

(Hayashi et al., 2014)

Other

Statement

Reference

Klc^sat, mael^sat has oocyte phenotype

(Hayashi et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Germline clones in females that are doubly homozygous for Klc^sat and mael^sat results in mis-positioning of the oocyte nucleus. Most eggs laid by these females have no dorsal appendages, and the remainder have reduced or fused dorsal appendages.

(Hayashi et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Associated with: Klc^sat.

(Hayashi et al., 2014)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

5R12

(Hayashi et al., 2014)

mael^sat

(Hayashi et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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