FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fruB2
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General Information
Symbol
Dmel\fruB2
Species
D. melanogaster
Name
FlyBase ID
FBal0296343
Feature type
allele
Associated gene
Dmel\fru
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(von Philipsborn et al., 2014)
Progenitor genotype
fruΔtra
(von Philipsborn et al., 2014)
Cytology
Description

Amino acid replacement: C665Y.

(von Philipsborn et al., 2014)

Mutation is in the B exon.

(von Philipsborn et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:18,423,035..18,423,035 [-]
Nucleotide change:

G18423035A

Amino acid change:

C665Y | fru-PG; C564Y | fru-PH; C574Y | fru-PK; C564Y | fru-PO

Reported amino acid change:

C665Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(von Philipsborn et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      fruB2/fruF males show significantly reduced copulation success compared to controls in single-pair courtship assays.

      fruB2/fruF males show courtship song defects: the interpulse interval of the pulse song is longer and more varied than normal. Sine song and the carrier frequency of pulse song are normal.

      fruB2/fruF males show a significant decrease in the number of aDT2/mAL neuronal cells per hemisphere compared to fru[+] males, but no significant change in the number of pMP4/P1, pIP10, dPR1, vPR1, vPR6, aSP1 or aSP2 neuronal cells per hemisphere.

      (von Philipsborn et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The overall mating ability in competitive mating assays can be ranked as follows: fru[+] > fruΔA.T:Hsap\MYC > fruB2 > fruC1.

      (von Philipsborn et al., 2014)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fruB2
      (Wohl et al., 2020, von Philipsborn et al., 2014)
      fruB
      (von Philipsborn et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)