FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pgcl1
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General Information
Symbol
Dmel\Pgcl1
Species
D. melanogaster
Name
FlyBase ID
FBal0296467
Feature type
allele
Associated gene
Dmel\Pgcl
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Mouri et al., 2014)
Progenitor genotype
Cytology
Description

Amino acid replacement: N122T.

(Mouri et al., 2014)

Amino acid replacement: K123Q.

(Mouri et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:437,043..437,043 [-]
Nucleotide change:

A437043C

Reported nucleotide change:

A?C

Amino acid change:

K123Q | Pgcl-PA

Reported amino acid change:

K123Q

Comment:

Two adjacent amino acids have base changes in Pgcl1.

(Mouri et al., 2014)
point_mutation
X:437,045..437,045 [-]
Nucleotide change:

A437045C

Reported nucleotide change:

A?C

Amino acid change:

N122T | Pgcl-PA

Reported amino acid change:

N122T

Comment:

Two adjacent amino acids have base changes in Pgcl1.

(Mouri et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous clones in the wing result in severe misorientation of wing hairs and loss of wing margin. At 23 hours after pupariation both mutant cells along the distal clone border and wild-type cells located distal and close to the clone border show misorientation of pre-hairs, while mutant cells deep within the clone show normal pre-hair polarity.

      (Mouri et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      Pgcl1 is partially rescued by PgclUAS.cMa/Scer\GAL4arm.PS

      (Mouri et al., 2014)
      Comments

      Expression of pclScer\UAS.cMa under the control of either Scer\GAL4da.PU or Scer\GAL4arm.PS rescues both the lethality of pcl1 homozygotes and the wing margin defect caused by homozygous pcl1 clones in the wing. Expression of pclScer\UAS.cMa under the control of Scer\GAL4arm.PS partially rescues the wing hair polarity defect caused by homozygous pcl1 clones in the wing.

      (Mouri et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      #11166
      (Mouri et al., 2014)
      Pgcl1
      pcl1
      (Mouri et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)