FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\insbΔ1
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General Information
Symbol
Dmel\insbΔ1
Species
D. melanogaster
Name
FlyBase ID
FBal0296584
Feature type
allele
Associated gene
Dmel\insb
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Caused by aberration
    Df(2R)insbΔ1
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    deletion
    2R:17,462,561..17,477,956 [-]
    Comment:

    Scer\FRT-mediated recombination between the two progenitor insertions has resulted in the deletion of the genomic sequence between them. The deletion is reported as 15,396 in length. Breakpoint 1 (corresponding to the P{XP}d00050 insertion site) was calculated as 15,395 bp upstream of the PBac{WH}f07683 insertion site since the P{XP}d00050 insertion site is unreported.

    (Coumailleau and Schweisguth, 2014)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        No clear developmental defects are observed in insbΔ1 mutant flies (in which the function of CG14478, Tes and qkr54B has been restored using P{CG14478-Tes-qkr54B-mCherry}, which comprises of the CG14478T:Disc\RFP-mCherry, TesT:Disc\RFP-mCherry and qkr54BT:Disc\RFP-mCherry alleles). The sensory bristles show a normal pattern on the body surface.

        (Coumailleau and Schweisguth, 2014)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        insbΔ1, Tes+t22, qkr54B+t22, CG14478+t22 is an enhancer of visible | dominant phenotype of HE31, insv23B

        (Coumailleau and Schweisguth, 2014)
        Phenotype Manifest In
        Enhancer of
        Suppressor of
        Statement
        Reference

        insbΔ1/Df(2R)BSC406 is a suppressor of macrochaeta phenotype of N55e11

        (Coumailleau and Schweisguth, 2014)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        No detectable macrochaetae phenotypes are observed in insv23B, insbΔ1 double mutant flies in which the function of CG14478, Tes and qkr54B has been restored using P{CG14478-Tes-qkr54B-mCherry} (which comprises of the CG14478T:Disc\RFP-mCherry, TesT:Disc\RFP-mCherry and qkr54BT:Disc\RFP-mCherry alleles).

        insv23B enhances the double-socket macrochaetae phenotype seen in HE31/+ mutants. The bristle loss phenotype is further enhanced by loss of insb, using insbΔ1, in which the function of CG14478, Tes and qkr54B has been restored using P{CG14478-Tes-qkr54B-mCherry} (which comprises of the CG14478T:Disc\RFP-mCherry, TesT:Disc\RFP-mCherry and qkr54BT:Disc\RFP-mCherry alleles).

        insbΔ1/Df(2R)BSC406 suppresses the bristle density phenotype seen in N55e11/+ mutant flies.

        The bristle loss phenotype seen in HE31/+ mutant flies is enhanced by loss of insb (using insbΔ1, in which the function of CG14478, Tes and qkr54B has been restored using P{CG14478-Tes-qkr54B-mCherry} (which comprises of the CG14478T:Disc\RFP-mCherry, TesT:Disc\RFP-mCherry and qkr54BT:Disc\RFP-mCherry alleles). Expression of insbT:Avic\GFP rescues this phenotype, returning the number of transformed macrochaetae to levels seen in HE31 heterozygotes alone.

        (Coumailleau and Schweisguth, 2014)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        This deficiency has been used as a null allele for insbΔ1 when in combination with P{CG14478-Tes-qkr54B-mCherry}.

        (Coumailleau and Schweisguth, 2014)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        insbΔ1
        Name Synonyms
        Secondary FlyBase IDs
          References (1)