FlyBase Allele Report: Dmel\GM130[Δ23]

General Information

Symbol

Dmel\GM130^Δ23

Species

D. melanogaster

Name

FlyBase ID

FBal0296641

Feature type

allele

Associated gene

Dmel\GM130

Associated Insertion(s)

Carried in Construct

Also Known As

dGM130^Δ23

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Zhou et al., 2014)

Progenitor genotype

P{RS3}GM130^CB-6408-3

(Zhou et al., 2014)

Cytology

Description

Imprecise excision of progenitor P{RS3}GM130^CB-6408-3.

(Zhou et al., 2014)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage

(Zhou et al., 2014)

fertile

(Zhou et al., 2014)

viable

(Zhou et al., 2014)

Phenotype Manifest In

dendrite

(Zhou et al., 2014)

dendritic arborizing neuron | larval stage

(Zhou et al., 2014)

dendritic branch point

(Zhou et al., 2014)

Golgi apparatus

(Zhou et al., 2014)

larval multidendritic class III neuron | larval stage

(Zhou et al., 2014)

microtubule

(Zhou et al., 2014)

Detailed Description

Statement

Reference

GM130^Δ23 third instar larval adipocytes do not show defects in the normal perinuclear distribution of microtubules.

(Sun et al., 2019)

The architecture of somal Golgi in larval dendritic arborization neurons is dramatically perturbed in GM130^Δ23 mutants. The ring-shaped Golgi units are randomly detected in mutant neurons. Instead, many Golgi compartments of irregular shape showing defects in compartmental organisation are present. GM130^Δ23 mutants show decreased percentage of multi-compartment Golgi distal dendrites, but do not show any difference in proximal dendrites between control and mutant neurons.

In GM130^Δ23 mutant neurons, microtubule growth initiation events are reduced in distal dendrites. Microtubule growth initiation at dendritic branch points is dramatically suppressed by GM130^Δ23.

The total number of dendritic branch points as well as the number of higher-order branches (fourth order and up) is significantly reduced in GM130^Δ23 mutant class III da neurons.

(Zhou et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

GM130^Δ23/GM130^Δ23 is a non-suppressor of fat cell | third instar larval stage phenotype of Scer\GAL4^{SPARC-MI00329-GAL4}, shot^JF02971

(Sun et al., 2019)

GM130^Δ23/GM130^Δ23 is a non-suppressor of microtubule | third instar larval stage phenotype of Scer\GAL4^{SPARC-MI00329-GAL4}, shot^JF02971

(Sun et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

65255

w^*; GM130^Δ23; TM2/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

GM130^Δ23

(Woodward et al., 2025, Kong et al., 2023, Zheng et al., 2020, Sun et al., 2019)

dGM130^Δ23

(Cheng et al., 2023, Zhou et al., 2014)

gm130 mutant

(Yagoubat and Conduit, 2025)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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