FB2021_01, released Feb 18, 2021

Allele: Dmel\GM130UAS.cZa

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General Information
Symbol
Dmel\GM130UAS.cZa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Zhou
FlyBase ID
FBal0296643
Feature type
allele
Associated gene
Dmel\GM130
Associated Insertion(s)
Carried in Construct
P{UAS-GM130.Z}
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - regulatory fusion
(Zhou et al., 2014)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{UAS-GM130.Z}
      Cytology
      Nature of the lesion
      Statement
      Reference

      UAS regulatory sequences drive expression of GM130.

      (Zhou et al., 2014)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UAS
      Encoded product / tool
      GM130
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Scer\GAL419-12>GM130Scer\UAS.cZa engenders multi-compartment Golgi outposts in dendrite shafts of larval dendritic arborization neurons. In contrast to the dendritic shafts, GM130Scer\UAS.cZa-expression does not significantly affect the compartment organisation of somal Golgi.

      The number of microtubule growth initiation events is significantly increased in the dendritic shafts of neurons expressing Scer\GAL419-12>GM130Scer\UAS.cZa. The increase is largely due to events associated with GM130-containing multi-comparment Golgi outposts.

      The total number of dendritic branch points as well as the number of higher-order branches (fourth order and up) is significantly reduced in class III da neurons expressing Scer\GAL419-12>GM130Scer\UAS.cZa.

      (Zhou et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      GM130Scer\UAS.cZa
      GM130UAS.cZa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Zhou
      Secondary FlyBase IDs
        References (1)