FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\McrK103
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General Information
Symbol
Dmel\McrK103
Species
D. melanogaster
Name
FlyBase ID
FBal0296686
Feature type
allele
Associated gene
Dmel\Mcr
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Bätz et al., 2014)
Mutagen
ethyl methanesulfonate
(Bätz et al., 2014)
Progenitor genotype
Cytology
Description

Amino acid replacement: R329term.

(Bätz et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:8,079,531..8,079,531 [-]
Nucleotide change:

C8079531T

Amino acid change:

R329term | Mcr-PA

Reported amino acid change:

R329term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Bätz et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant embryos have elongated trachea compared to controls. The dorsal trunk is 20% longer than normal in mutant stage 16 embryos. This is not due to an increase in tracheal cell number, but is due to the apical surfaces of dorsal trunk cells being axially longer than normal.

      The paracellular barrier function of the trachea and hindgut epithelia is compromised in mutant animals (assayed using a dye exclusion assay). Septate junctions are missing from the apicolateral membrane of hindgut cells in mutant stage 17 embryos.

      (Bätz et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      McrEY07421

      (Bätz et al., 2014)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      McrK103
      (Byri et al., 2015, Bätz et al., 2014)
      lufK103
      (Bätz et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)