FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pakpsg4b
Open Close
General Information
Symbol
Dmel\Pakpsg4b
Species
D. melanogaster
Name
FlyBase ID
FBal0297310
Feature type
allele
Associated gene
Dmel\Pak
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ihry and Bashirullah, 2014)
Progenitor genotype
Cytology
Description

Amino acid replacement: G439S.

(Ihry and Bashirullah, 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:6,358,525..6,358,525 [+]
Nucleotide change:

G6358525A

Amino acid change:

G439S | Pak-PA; G439S | Pak-PB; G439S | Pak-PC; G439S | Pak-PE; G575S | Pak-PF; G575S | Pak-PG; G575S | Pak-PH; G575S | Pak-PI; G439S | Pak-PJ

Reported amino acid change:

G439S

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Ihry and Bashirullah, 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pakpsg4a/Pakpsg4b animals show normal mid-third instar (wandering behaviour) and late larval (everting anterior spiracles, barrel shape, midgut programmed cell death) ecdysone-triggered responses. The prepupal ecdysone-triggered responses of head eversion, wing and leg inflation are normal, but leg extension at this stage is defective. In the salivary gland, mid-third instar glue synthesis is normal, late larval glue secretion is normal, but prepupal salivary gland programmed cell death is defective.

      (Ihry and Bashirullah, 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Pakpsg4b
      psg4b
      (Ihry and Bashirullah, 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)