FlyBase Allele Report: Dmel\lncRNA:let7C[KO1]

General Information

Symbol

Dmel\lncRNA:let7C^KO1

Species

D. melanogaster

Name

FlyBase ID

FBal0297475

Feature type

allele

Associated gene

Dmel\lncRNA:let7C

Associated Insertion(s)

Carried in Construct

Also Known As

let-7-C^KO1

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Caused by aberration

Df(2L)let-7-C^KO1

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with lncRNA:let7C^+tSa

(Wu et al., 2012)

abnormal neuroanatomy (with lncRNA:let7C^KO2)

(Wu et al., 2012)

abnormal neuroanatomy | adult stage (with lncRNA:let7C^KO2), with lncRNA:let7C^Δmir-125

(Chawla et al., 2016)

abnormal neuroanatomy | adult stage (with lncRNA:let7C^KO2), with lncRNA:let7C^Δmir-let7

(Chawla et al., 2016)

abnormal neuroanatomy | dominant

(Wu et al., 2012)

abnormal neuroanatomy | somatic clone

(Wu et al., 2012)

decreased cell number | adult stage (with lncRNA:let7C^KO2), with lncRNA:let7C^Δmir-125

(Chawla et al., 2016)

decreased cell number | adult stage (with lncRNA:let7C^KO2), with lncRNA:let7C^Δmir-let7

(Chawla et al., 2016)

Phenotype Manifest In

alpha/beta posterior Kenyon cell | adult stage (with lncRNA:let7C^KO2), with lncRNA:let7C^Δmir-125

(Chawla et al., 2016)

alpha/beta posterior Kenyon cell | adult stage (with lncRNA:let7C^KO2), with lncRNA:let7C^Δmir-let7

(Chawla et al., 2016)

mushroom body

(Wu et al., 2012)

mushroom body, with lncRNA:let7C^+tSa

(Wu et al., 2012)

mushroom body (with lncRNA:let7C^KO2)

(Wu et al., 2012)

mushroom body | somatic clone

(Wu et al., 2012)

Detailed Description

Statement

Reference

Adults transheterozygous for lncRNA:let7C^KO2/lncRNA:let7C^KO1 and also bearing lncRNA:let7C^Δmir-let7 or lncRNA:let7C^Δmir-125 exhibit a decrease in the number of pioneer α/β mushroom body neurons.

(Chawla et al., 2016)

let-7-C^KO1 mutant neurons display delays in the α'/β' to p.α/β and p.α/β to α/β transitions in mushroom body neuron identities during neurogenesis, compared to wild type. Consistent with this, let-7-C^KO1/let-7-C^KO2 adults show an increased number of earlier born α'/&bgr' neurons, and a decreased number of later born p.α/β neurons. While the morphology of mutant mushroom bodies is grossly normal, some p.α/β and α/β axons inappropriately cross the midline.

let-7-C^KO1/+ adults show a reduction in p.α/β mushroom body neurons.

(Wu et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

lncRNA:let7C^KO1 has abnormal neuroanatomy | dominant phenotype, suppressible by chinmo[+]/chinmo¹

(Wu et al., 2012)

Suppressor of

Statement

Reference

lncRNA:let7C^KO1 is a suppressor of abnormal eye color phenotype of w^ORF.ab3'UTR

(Wu et al., 2012)

lncRNA:let7C^KO1 is a suppressor of abnormal eye color phenotype of w^{ORF.chinmo3'UTR}

(Wu et al., 2012)

Phenotype Manifest In

Suppressed by

Statement

Reference

lncRNA:let7C^KO1 has mushroom body phenotype, suppressible by chinmo[+]/chinmo¹

(Wu et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

w^ORF.ab3'UTR flies (in a w[-] background) whose eyes are composed exclusively of let-7-C^KO1 mutant cells display a darker eye colour compared to w^ORF.ab3'UTR alone.

w^{ORF.chinmo3'UTR} flies (in a w[-] background) whose eyes are composed exclusively of let-7-C^KO1 mutant cells display a darker eye colour compared to w^{ORF.chinmo3'UTR} alone.

The reduction in p.α/β mushroom body neurons in let-7-C^KO1/+ adults is restored to normal numbers by chinmo¹/+.

(Wu et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

let-7-C^KO1

(Kitatani et al., 2020, Chawla et al., 2016)

lncRNA:let7C^KO1

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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