FlyBase Allele Report: Dmel\Vps13D[MI11101]

General Information

Symbol

Dmel\Vps13D^MI11101

Species

D. melanogaster

Name

FlyBase ID

FBal0297549

Feature type

allele

Associated gene

Dmel\Vps13D

Associated Insertion(s)

Mi{MIC}Vps13D^MI11101

Carried in Construct

Also Known As

Vps13D^MI

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

Mi{MIC}Vps13D^MI11101

Cytology

Description

Allele components

Component

Use(s)

Inserted element

Also carries

integrase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:12,762,848..12,762,848 [-]

(Restrepo et al., 2026, Wang et al., 2022, Shen et al., 2021, Shen et al., 2021, Bellen, 2014.8.14)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of autosomal recessive spinocerebellar ataxia 4

CEA

(Seong et al., 2018)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell size | pupal stage | somatic clone

(Anding et al., 2018)

lethal

(Anding et al., 2018)

lethal (with Df(3L)BSC631)

(Anding et al., 2018)

lethal - all die before end of second instar larval stage

(Seong et al., 2018)

Phenotype Manifest In

endoplasmic reticulum | prepupal stage (with Vps13D^ΔUBA)

(Shen et al., 2021)

gut | prepupal stage (with Vps13D^ΔUBA)

(Shen et al., 2021)

larval brain | larval stage

(Seong et al., 2018)

midgut | pupal stage | somatic clone

(Anding et al., 2018)

mitochondrion | larval stage

(Seong et al., 2018)

mitochondrion | prepupal stage (with Vps13D^ΔUBA)

(Shen et al., 2021)

Detailed Description

Statement

Reference

Vps13D^ΔUBA/Vps13D^MI11101 transheterozygotes exhibit enlarged mitochondria, and increased contact between mitochondria and ER, in the intestine 2h after pupariation.

(Shen et al., 2021)

The cell size in pupal (2hr after pupariation) midgut somatic clones mutant for Vps13D^MI11101 is significantly increased and the cells contain fewer Atg8a puncta compared to surrounding heterozygous cells and display mitochondrial clearance defects.

(Anding et al., 2018)

Mitochondria in Vps13D^MI11101 larval brains appear as singular, enlarged objects, instead of forming the fine mitochondrial networks observed in controls.

(Seong et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Vps13D^MI11101/Vps13D^ΔUBA has gut | prepupal stage phenotype, suppressible by Scer\GAL4^NP0001/Marf^KK105681

(Shen et al., 2021)