FB2026_02 , released June 18, 2026
Allele: Hsap\APParctic.Aβ42.NSP.UAS
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General Information
Symbol
Hsap\APParctic.Aβ42.NSP.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0297912
Feature type
allele
Associated gene
Hsap\APP
Associated Insertion(s)
Carried in Construct
M{UAS-ArcticAβ42.NSP}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Kruppa et al., 2013)
Progenitor genotype
Carried in construct
M{UAS-ArcticAβ42.NSP}
Cytology
Description

UASt regulatory sequences drive expression of an Aβ42 peptide carrying the Arctic mutation (amino acid replacement E22G). No signal peptide sequence is present.

(Kruppa et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\APP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The lifespan of flies expressing Hsap\APParctic.Aβ42.NSP.Scer\UAS.att under the control of Scer\GAL4elav-C155 does not differ from control flies, indicating that cytoplasmic Hsap\APP is not toxic.

      In flies expressing Hsap\APParctic.Aβ42.NSP.Scer\UAS.att, the appearance of plaque-like deposits cannot be induced.

      (Kruppa et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Knockdown of Psa, through expression of PsaNIG.1009R, reduces the longevity of flies expressing Hsap\APParctic.Aβ42.NSP.Scer\UAS.att under the control of Scer\GAL4elav-C155, to the same level as when PsaNIG.1009R is expressed in a wild-type background.

      (Kruppa et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\APParctic.Aβ42.NSP.Scer\UAS.att
      Hsap\APParctic.Aβ42.NSP.Scer\UAS
      Hsap\APParctic.Aβ42.NSP.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)