FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Col4a1S0120
Open Close
General Information
Symbol
Dmel\Col4a1S0120
Species
D. melanogaster
Name
FlyBase ID
FBal0297998
Feature type
allele
Associated gene
Dmel\Col4a1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

temperature conditional loss of function allele

Mutagen
Nature of the Allele
Allele class

temperature conditional loss of function allele

(Hollfelder et al., 2014)
Mutagen
ethyl methanesulfonate
(Hollfelder et al., 2014)
Progenitor genotype
Cytology
Description

Amino acid replacement: G1378S.

(Hollfelder et al., 2014)

Nucleotide substitution: G?A.

(Hollfelder et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:5,035,261..5,035,261 [+]
Nucleotide change:

G5035261A

Reported nucleotide change:

G?A

Amino acid change:

G1378S | Col4a1-PA; G1378S | Col4a1-PB; G1378S | Col4a1-PC

Reported amino acid change:

G1378S

(Hollfelder et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Most Cg25CS0120/Cg25CS3064 and Cg25CS0120/Df(2L)Exel7022 embryos show a robust alary muscle detachment phenotype. Alary muscle detachment in Df(2L)Exel7022 transheterozygous embryos is more penetrant at higher temperatures.

      Cg25CS0120/Cg25CS3064 is embryonic lethal at 25[o]C, but if kept at 19[o]C some animals develop into early L2 larvae.

      (Hollfelder et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Cg25CS0120
      (Hollfelder et al., 2014)
      Col4a1S0120
      Name Synonyms
      Secondary FlyBase IDs
        References (1)