FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Col4a1S1348
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General Information
Symbol
Dmel\Col4a1S1348
Species
D. melanogaster
Name
FlyBase ID
FBal0298000
Feature type
allele
Associated gene
Dmel\Col4a1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

temperature conditional loss of function allele

Mutagen
Nature of the Allele
Allele class

temperature conditional loss of function allele

(Hollfelder et al., 2014)
Mutagen
ethyl methanesulfonate
(Hollfelder et al., 2014)
Progenitor genotype
Cytology
Description

Amino acid replacement: G1031R.

(Hollfelder et al., 2014)

Nucleotide substitution: G?A.

(Hollfelder et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:5,034,138..5,034,138 [+]
Nucleotide change:

G5034138A

Reported nucleotide change:

G?A

Amino acid change:

G1031R | Col4a1-PA; G1031R | Col4a1-PB; G1031R | Col4a1-PC

Reported amino acid change:

G1031R

(Hollfelder et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous, Cg25CS1348/Cg25CS3064 or Cg25CS1348/Df(2L)Exel7022 embryos show a relatively weak and not fully penetrant detached alary muscle phenotype at 25[o]C. Alary muscle detachment in Df(2L)Exel7022 transheterozygous embryos is more penetrant at higher temperatures.

      Adult escapers are observed if combined with Cg25CS3064 or Cg25CDTS-L3 and grown at 19[o]C, while at 25[o]C these trans-heterozygotes die either during larval growth or in pupal stages.

      (Hollfelder et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Cg25CS1348
      (Hollfelder et al., 2014)
      Col4a1S1348
      Name Synonyms
      Secondary FlyBase IDs
        References (1)