FB2026_02 , released June 18, 2026
Allele: Dmel\Xbp1Exc1
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General Information
Symbol
Dmel\Xbp1Exc1
Species
D. melanogaster
Name
Excision 1
FlyBase ID
FBal0298051
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Cytology
Description

Imprecise excision of the P{SUPor-P} element in P{SUPor-P}Hmg-2KG05183 has resulted in a deletion. In the spliced form of Xbp1, the last 278 codons (at the 3' region of the coding sequence) are deleted and 4 new codons (GITL) are present before the introduction of a nonsense stop codon. In the unspliced form, the last 87 codons are deleted and 5 new codons (ELPCS) are followed by a nonsense stop codon.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Comment:

1696 bp deletion resulting from the imprecise excision of P{SUPor-P}Hmg-2KG05183 removes sequences from 2R:17 ,032,105-17,033,800 in release 5 coordinates.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous Xbp1Exc1 mutant larvae exposed to the ER stress-inducing drug tunicamycin arrest development at the first instar larval stage and die two to three days after egg laying.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Xbp1Exc1
Name Synonyms
Excision 1
Secondary FlyBase IDs
    References (1)