FB2026_02 , released June 18, 2026
Allele: Dmel\inaEUAS.cLd
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General Information
Symbol
Dmel\inaEUAS.cLd
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct d of Lin
FlyBase ID
FBal0298299
Feature type
allele
Associated gene
Dmel\inaE
Associated Insertion(s)
Carried in Construct
P{UAS-inaE.PD}
Key Links
Transgenic product class
wild_type
(Lin et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Lin et al., 2014)
Mutagen
in vitro construct
(Lin et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-inaE.PD}
Cytology
Description

UAS regulatory sequences drive expression of the long 2214-nt PD isoform of inaE.

(Lin et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
inaE
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of inaEScer\UAS.cLd under the control of Scer\GAL4GMR.PU results in a 41% increase in mean lifespan compared with Scer\GAL4GMR.PU alone and 16% compared with inaEScer\UAS.cLd alone.

      Compared with wild-type, overexpression of inaEScer\UAS.cLd under the control of Scer\GAL4da.PU increases mean lifespan.

      (Lin et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      NOT Enhancer of
      Statement
      Reference

      inaEUAS.cLd, Scer\GAL4da.PU is a non-enhancer of long lived phenotype of S6kKQ.UAS, Scer\GAL4da.PU

      (Lin et al., 2014)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Simultaneous expression of inaEScer\UAS.cLd and S6kKQ.Scer\UAS both under the control of Scer\GAL4da.PU does not further extend lifespan compared with the expression of either transgene alone.

      (Lin et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      inaEScer\UAS.cLd
      inaEUAS.cLd
      Name Synonyms
      Saccharomyces cerevisiae UAS construct d of Lin
      Secondary FlyBase IDs
        References (1)