FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\rdgAGD1518
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General Information
Symbol
Dmel\rdgAGD1518
Species
D. melanogaster
Name
FlyBase ID
FBal0210442
Feature type
allele
Associated gene
Dmel\rdgA
Associated Insertion(s)
Carried in Construct
P{GD1518}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD1518}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD1518
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Scer\GAL4GMR.PU>rdgAGD1518 significantly increases mean life span compared with wild-type.

      (Lin et al., 2014)

      Adults expressing rdgAGD1518 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)

      Expression under the control of Scer\GAL4pnr-MD237 may result in semi-lethality, depending on the insertion line used.

      (Mummery-Widmer et al., 2009)

      The electroantennograms of animals expressing rdgAGD1518 under the control of Scer\GAL4Or83b.2.642.T:Hsim\VP22 show a significant decrease in amplitude compared to controls in response to a number of odours (ethyl acetate, butanol, propionic acid, benzaldehyde and iso-amyl acetate).

      (Kain et al., 2008)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT Enhancer of
      Statement
      Reference

      rdgAGD1518/Scer\GAL4GMR.PU is a non-enhancer of long lived phenotype of Scer\GAL4GMR.PU, inaEUAS.cLd

      (Lin et al., 2014)

      Scer\GAL4da.PU/rdgAGD1518 is a non-enhancer of long lived phenotype of Scer\GAL4GMR.PU, inaEUAS.cLd

      (Lin et al., 2014)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Simultaneous expression of inaEScer\UAS.cLd and rdgAGD1518 both under the control of Scer\GAL4GMR.PU does not further extend lifespan of that achieved by either transgene-expression independently.

      (Lin et al., 2014)

      Co-expression of Gα49BdsRNA.Scer\UAS.1f1 reduces the decrease in the amplitude of the electroantennogram in response to a number of odours (ethyl acetate, butanol, propionic acid, benzaldehyde and iso-amyl acetate) that is seen in animals expressing rdgAGD1518 under the control of Scer\GAL4Or83b.2.642.T:Hsim\VP22.

      (Kain et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      rdgAGD1518
      Name Synonyms
      Secondary FlyBase IDs
        References (8)