FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Rnor\DccUAS.Tag:MYC
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General Information
Symbol
Rnor\DccUAS.Tag:MYC
Species
R. norvegicus
Name
FlyBase ID
FBal0298360
Feature type
allele
Associated gene
Rnor\Dcc
Associated Insertion(s)
Carried in Construct
M{UAS-DCC-Myc}
Transgenic product class
wild_type
(O'Donnell and Bashaw, 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(O'Donnell and Bashaw, 2013)
Mutagen
in vitro construct
(O'Donnell and Bashaw, 2013)
Progenitor genotype
Carried in construct
M{UAS-DCC-Myc}
Cytology
Description

10xUAS regulatory sequences drive expression of the wild-type Rnor\Dcc coding sequence, tagged at the C-terminal with six copies of Tag:MYC.

(O'Donnell and Bashaw, 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Rnor\Dcc
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Rnor\DccScer\UAS.T:Hsap\MYC in an ipsilaterally projecting subset of neurons, under the control of Scer\GAL4ap-md544, results in axons from these neurons projecting aberrantly across the midline.

      (O'Donnell and Bashaw, 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Suppressor of
      NOT Suppressor of
      Phenotype Manifest In
      Suppressed by
      Suppressor of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      A Df(1)NetABΔ background suppresses the aberrant midline crossing seen in ipsilaterally-projecting neurons expressing Rnor\DccScer\UAS.T:Hsap\MYC under the control of Scer\GAL4ap-md544.

      Expression of Rnor\DccScer\UAS.T:Hsap\MYC under the control of Scer\GAL4eg-Mz360 rescues the EW commissural axon defects seen in fra3/Df(2R)vg135 embryos.

      Expression of Rnor\DccScer\UAS.T:Hsap\MYC under the control of Scer\GAL4eg-Mz360 rescues the midline crossing defects found in EW neurons in fra3/fra4 mutants.

      Pan-neuronal expression of Rnor\DccScer\UAS.T:Hsap\MYC (under the control of Scer\GAL4elav.PLu) does not rescue the motor guidance defects or longitudinal connective defects found in fra3 mutants and only mildly rescues the commissural guidance phenotype.

      (O'Donnell and Bashaw, 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Rnor\DccScer\UAS.T:Hsap\MYC
      Rnor\DccUAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)