FB2026_03 , released September 17, 2026
Allele: Dmel\Fbxl7W389X
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General Information
Symbol
Dmel\Fbxl7W389X
Species
D. melanogaster
Name
FlyBase ID
FBal0298384
Feature type
allele
Associated gene
Dmel\Fbxl7
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Bosch et al., 2014)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Premature stop codon upstream of all conserved domains.

    (Bosch et al., 2014)

    Amino acid replacement: W389term.

    (Bosch et al., 2014)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:15,931,198..15,931,198 [+]
    Nucleotide change:

    G15931198A

    Amino acid change:

    W389term | Fbxl7-PA

    Reported amino acid change:

    W389term

    Comment:

    G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Bosch et al., 2014)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mutant clones are over-represented in the eye compared to controls, demonstrating increased growth of the mutant tissue.

        (Bosch et al., 2014)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Fbxl7W389X
        (Bosch et al., 2014)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)