FlyBase Allele Report: Dmel\Su(H)[CTD.UAS.Tag:MYC]

General Information

Symbol

Dmel\Su(H)^{CTD.UAS.Tag:MYC}

Species

D. melanogaster

Name

FlyBase ID

FBal0298390

Feature type

allele

Associated gene

Dmel\Su(H)

Associated Insertion(s)

Carried in Construct

M{UAS-myc-Su(H)CTD}

Key Links

Transgenic product class

inframe_deletion

(Maier et al., 2013)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Maier et al., 2013)

Mutagen

in vitro construct

(Maier et al., 2013)

Progenitor genotype

Carried in construct

M{UAS-myc-Su(H)CTD}

Cytology

Description

UASt regulates expression of the C-terminal domain of Su(H), representing codons 417-528, with a Tag:MYC tag at the N-terminus. The CTD contains the binding domain for the N ankyrin repeats as well as for H, but has no DNA binding capacity.

(Maier et al., 2013)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Su(H)

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size, with Scer\GAL4^bi-omb-Gal4

(Maier et al., 2013)

increased cell number, with Scer\GAL4^bi-omb-Gal4

(Maier et al., 2013)

Phenotype Manifest In

adult external thorax, with Scer\GAL4^Bx-MS1096

(Maier et al., 2013)

mechanosensory chaeta, with Scer\GAL4^Bx-MS1096

(Maier et al., 2013)

wing disc, with Scer\GAL4^bi-omb-Gal4

(Maier et al., 2013)

Detailed Description

Statement

Reference

Scer\GAL4^Bx-MS1096-mediated expression of Su(H)^{CTD.T:Hsap\MYC} causes a transformation of shaft into socket cell fate during bristle development, affecting the majority of micro- and macrochaetae.

Scer\GAL4^bi-omb-Gal4-mediated expression of Su(H)^{CTD.T:Hsap\MYC} stimulates wing discs to over-proliferate.

(Maier et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

H^UAS.cMb, Scer\GAL4^Bx-MS1096, Su(H)^{CTD.UAS.Tag:MYC} has viable phenotype

(Maier et al., 2013)

Phenotype Manifest In

Suppressor of

Statement

Reference

Su(H)^{CTD.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096 is a suppressor of mechanosensory chaeta phenotype of H^UAS.cMb, Scer\GAL4^Bx-MS1096

(Maier et al., 2013)

Su(H)^{CTD.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096 is a suppressor of adult external thorax phenotype of H^UAS.cMb, Scer\GAL4^Bx-MS1096

(Maier et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Scer\GAL4^Bx-MS1096-mediated co-expression of H^Scer\UAS.cMb and Su(H)^{CTD.T:Hsap\MYC} results in mild phenotypes and flies hatch normally. Bristle development is subtly disturbed - double sockets are occasionally seen, as are bristle loss and a slightly higher bristle density.

Scer\GAL4^bi-omb-Gal4-mediated co-expression of H^Scer\UAS.cMb and Su(H)^{CTD.T:Hsap\MYC} has almost no influence on disc size.

(Maier et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Su(H)^{CTD.T:Hsap\MYC}

Su(H)^{CTD.UAS.Tag:MYC}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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