FlyBase Allele Report: Dmel\dos[RNAi.UAS.1629-2112]

General Information

Symbol

Dmel\dos^{RNAi.UAS.1629-2112}

Species

D. melanogaster

Name

FlyBase ID

FBal0298836

Feature type

allele

Associated gene

Dmel\dos

Associated Insertion(s)

Carried in Construct

P{UAS-dos.RNAi.1629-2112}

Key Links

Transgenic product class

RNAi_reagent

(Lu et al., 2014)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Lu et al., 2014)

Mutagen

in vitro construct

(Lu et al., 2014)

Progenitor genotype

Carried in construct

P{UAS-dos.RNAi.1629-2112}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat of nucleotides 1629-2112 of dos.

(Lu et al., 2014)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dos

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

glial cell, with Scer\GAL4^repo, Scer\GAL80^ts.αTub84B

(Lu et al., 2014)

vesicle, with Scer\GAL4^repo, Scer\GAL80^ts.αTub84B

(Lu et al., 2014)

Detailed Description

Statement

Reference

Adult glia expressing dos^{Scer\UAS.dsRNA} (through Scer\GAL4^repo and Scer\GAL80^ts.αTub84B) exhibit a significant delay in engulfment of axonal debris.

(Lu et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

A Sos^JC2/+ background suppresses the delay in axonal debris clearance after axotomy found upon knockdown of dos (through expression of dos^{Scer\UAS.dsRNA} under the control of Scer\GAL4^repo and Scer\GAL80^ts.αTub84B).

(Lu et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

dos^{RNAi.UAS.1629-2112}

dos^{Scer\UAS.dsRNA}

dos^UAS.RNAi

dos^UAS.dsRNA

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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