FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\piwi5'Tag:MYC
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General Information
Symbol
Dmel\piwi5'Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0298955
Feature type
allele
Associated gene
Dmel\piwi
Associated Insertion(s)
Carried in Construct
P{5'-myc-piwi.Ca4B2G}
P{5'-myc-piwi}
Also Known As
myc-piwi, P[myc-piwi]
Key Links
Transgenic product class
wild_type
(Cox et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Cox et al., 2000)
Mutagen
in vitro construct
(Cox et al., 2000)
Progenitor genotype
piwi+t6.8
(Cox et al., 2000)
Carried in construct
P{5'-myc-piwi.Ca4B2G}
P{5'-myc-piwi}
Cytology
Description

A Tag:MYC tag has been inserted at the 5' end of the piwi open reading frame (between amino acid residues 3 and 4).

(Cox et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
piwi
Encoded product / tool
piwi
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Cycle 14 embryos produced by females carrying 4 copies of the piwi5'T:Hsap\MYC transgene have around 50 pole cells, while embryos produced by females carrying 6 copies of piwi5'T:Hsap\MYC have around 66 pole cells, compared to 24 pole cells in wild-type embryos. The embryos from the transgene-carrying mothers show no increase in the number of somatic cells and no defects in either abdominal patterning or embryonic polarity.

      (Megosh et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The ability of geldanamycin to increase the frequency of the ectopic eye outgrowth phenotype in KrIf-1 homozygous females is reduced if the females are also carrying piwi5'T:Hsap\MYC.

      (Gangaraju et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Expression of two copies of piwi5'T:Hsap\MYC rescues the ovary phenotypes and egg laying defects seen in homozygous piwi1 mutant flies.

      (Darricarrère et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      piwi5'T:Hsap\MYC
      piwi5'Tag:MYC
      piwiattB.T:Hsap\MYC
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0103600
      • FBal0287899
      References (15)