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General Information
Symbol
Dmel\piwi5'T:Hsap\MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0298955
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
myc-piwi, P[myc-piwi]
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

A Tag:MYC tag has been inserted at the 5' end of the piwi open reading frame (between amino acid residues 3 and 4).

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Cycle 14 embryos produced by females carrying 4 copies of the piwi5'T:Hsap\MYC transgene have around 50 pole cells, while embryos produced by females carrying 6 copies of piwi5'T:Hsap\MYC have around 66 pole cells, compared to 24 pole cells in wild-type embryos. The embryos from the transgene-carrying mothers show no increase in the number of somatic cells and no defects in either abdominal patterning or embryonic polarity.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The ability of geldanamycin to increase the frequency of the ectopic eye outgrowth phenotype in KrIf-1 homozygous females is reduced if the females are also carrying piwi5'T:Hsap\MYC.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of two copies of piwi5'T:Hsap\MYC rescues the ovary phenotypes and egg laying defects seen in homozygous piwi1 mutant flies.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
piwi5'T:Hsap\MYC
piwiattB.T:Hsap\MYC
Name Synonyms
Secondary FlyBase IDs
  • FBal0103600
  • FBal0287899
References (13)