FB2026_02 , released June 18, 2026
Allele: Hsap\ATXN232Q.ΔPAM2.UAS.Tag:MYC
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General Information
Symbol
Hsap\ATXN232Q.ΔPAM2.UAS.Tag:MYC
Species
H. sapiens
Name
FlyBase ID
FBal0298971
Feature type
allele
Associated gene
Hsap\ATXN2
Associated Insertion(s)
Carried in Construct
P{UAS-ATXN2.32Q.ΔPAM2.MYC}
Key Links
Transgenic product class
inframe_deletion
(Kim et al., 2014)
trinucleotide_repeat_expansion
(Kim et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Kim et al., 2014)
trinucleotide_repeat_expansion
(Kim et al., 2014)
Mutagen
in vitro construct
(Kim et al., 2014)
Progenitor genotype
Hsap\ATXN232Q.UAS
(Kim et al., 2014)
Carried in construct
P{UAS-ATXN2.32Q.ΔPAM2.MYC}
Cytology
Description

The PAM2 domain (amino acids 920-932) has been deleted from Hsap\ATXN2 in Hsap\ATXN232Q.UAS.

(Kim et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\ATXN2
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Kim et al., 2014)
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\ATXN232Q.ΔPAM2.Scer\UAS.T:Hsap\MYC does not enhance the eye phenotype seen when Hsap\TARDBPScer\UAS.cEa is expressed under the control of Scer\GAL4GMR.PU. The reduction in lifespan induced by the expression of Hsap\TARDBPScer\UAS.cEa (under the control of Scer\GAL4elav.PLu) and climbing defects (under the control of Scer\GAL4elav.Switch.PO and raised with RU486) are also not enhanced.

      Co-expression of pAbpScer\UAS.cSa and Hsap\ATXN232Q.ΔPAM2.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.PU does not induce retinal degeneration.

      (Kim et al., 2014)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\ATXN232Q.ΔPAM2.Scer\UAS.T:Hsap\MYC
      Hsap\ATXN232Q.ΔPAM2.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (3)