FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\FoxK44
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General Information
Symbol
Dmel\FoxK44
Species
D. melanogaster
Name
FlyBase ID
FBal0298977
Feature type
allele
Associated gene
Dmel\FoxK
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Casas-Tinto et al., 2008)
Progenitor genotype
FoxKEP3428
(Casas-Tinto et al., 2008)
Cytology
Description

fd68A44 mutants carry a deletion of 2bp at the insertion site of P{EP}fd68AEP3428 and contains a reinsertion of a fragment of the p-element in exon 3 that generates a premature STOP codon 28 nucleotides after the insertion, resulting in a truncated protein that retains the FHA domain but lacks the FH domain.

(Casas-Tinto et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Early midgut differentiation is normal in fd68A44 mutant embryos until stage 15, when the midgut is composed of a single vesicle. During stage 16 three constrictions generate the four vesicles of the normal midgut. However, fd68A44 homozygous embryos form a single midgut constriction and two gastric vesicles. The midgut does not develop further.

      (Casas-Tinto et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Double heterozygous dpps12; fd68A44 mutants exhibit almost 100% lethality.

      Double heterozygous dpps8; fd68A44 mutants exhibit almost 100% viability.

      Double heterozygous dpphr27; fd68A44 mutants exhibit almost 80% viability.

      (Casas-Tinto et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      FoxK44
      (Casas-Tinto et al., 2008)
      fd68A44
      Name Synonyms
      Secondary FlyBase IDs
        References (1)