FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mmp2Y675N
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General Information
Symbol
Dmel\Mmp2Y675N
Species
D. melanogaster
Name
FlyBase ID
FBal0299610
Feature type
allele
Associated gene
Dmel\Mmp2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Wang and Page-McCaw, 2014)
Progenitor genotype
Cytology
Description

Amino acid replacement: Y675N.

(Wang and Page-McCaw, 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:9,612,346..9,612,346 [-]
Nucleotide change:

T9612346A

Amino acid change:

Y675N | Mmp2-PB; Y523N | Mmp2-PC; Y567N | Mmp2-PD

Reported amino acid change:

Y675N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. Mutation mapped relative to isoform Mmp2-PB.

(Wang and Page-McCaw, 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mmp2Y675N/Df(2R)BSC132 females show an increase in average cell number in the stalks between egg chambers after being shifted to the restrictive temperature.

      (Wang and Page-McCaw, 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Df(2R)BSC132/Mmp2Y675N has stalk follicle cell | increased number | heat sensitive phenotype, suppressible by wg[+]/wgl-8

      (Wang and Page-McCaw, 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increase in average cell number in the stalks between egg chambers which is seen in Mmp2Y53N/Df(2R)BSC132 and in Mmp2Y675N/Df(2R)BSC132 females after being shifted to the restrictive temperature is dominantly suppressed if the females also carry a single copy of wgl-17.

      (Wang and Page-McCaw, 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Mmp2Y675N
      (Wang and Page-McCaw, 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)