FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dnaaf527
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General Information
Symbol
Dmel\Dnaaf527
Species
D. melanogaster
Name
FlyBase ID
FBal0299642
Feature type
allele
Associated gene
Dmel\Dnaaf5
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Diggle et al., 2014)
Mutagen
P-element activity
(Diggle et al., 2014)
Progenitor genotype
P{EPgy2}NK7.1EY06677
(Diggle et al., 2014)
Caused by aberration
Df(3R)Dnaaf527
Cytology
Description

Imprecise excision of the progenitor insertion, generating a 992 bp deletion encompassing the transcriptional and translational start sites of HEATR2.

(Diggle et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:14,360,748..14,361,739 [-]
Comment:

A 992 deletion resulting from the imprecise excision of P{EPgy2}NK7.1EY06677 that includes the HEATR2 5' UTR and 390 bp of coding sequence.

(Diggle et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  primary ciliary dyskinesia
      CEA
      (Diggle et al., 2014)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous larvae are smaller than controls with no obvious morphological defects.

      (Diggle et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG3132027
      (Morris, 2022.8.30, Diggle et al., 2014)
      Dnaaf527
      HEATR227
      Name Synonyms
      Secondary FlyBase IDs
        References (2)