FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Rbbp5null
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General Information
Symbol
Dmel\Rbbp5null
Species
D. melanogaster
Name
FlyBase ID
FBal0301072
Feature type
allele
Associated gene
Dmel\Rbbp5
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Komori et al., 2014)
Progenitor genotype
P{EP}G4226
(Komori et al., 2014)
Cytology
Description

Imprecise excision of the P{EP}G4226 progenitor insertion.

(Komori et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:20,346,182..20,347,949 [-]
Comment:

A deletion resulting from the imprecise excision of the P{EP}G4226 progenitor insertion, which removes most of Rbbp5. 35 bases of P element and other sequence remain at the site of the insertion.

(Komori and Lee, 2016.8.10)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Type II neuroblasts in homozygous clones in the larval brain adopt a type I neuroblast identity (as determined by marker expression and the direct generation of ganglion mother cells).

      (Komori et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Rbbp5null is rescued by Scer\GAL4unspecified/Rbbp5UAS.FL.Tag:MYC

      (Komori et al., 2014)
      Not rescued by

      Rbbp5null is not rescued by Rbbp5SG.UAS.Tag:MYC/Scer\GAL4unspecified

      (Komori et al., 2014)
      Comments

      Expression of Rbbp5Scer\UAS.FL.T:Hsap\MYC using a Scer\GAL4 driver completely restores neuroblast II identity in homozygous Rbbp5null clones in the larval brain.

      Expression of Rbbp5SG.Scer\UAS.T:Hsap\MYC using a Scer\GAL4 driver does not restore neuroblast II identity in homozygous Rbbp5null clones in the larval brain.

      (Komori et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Rbbp5null
      (Komori and Lee, 2016.8.10)
      rbbp5null
      (Komori et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)