FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\IscUS20A
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General Information
Symbol
Dmel\IscUS20A
Species
D. melanogaster
Name
FlyBase ID
FBal0301099
Feature type
allele
Associated gene
Dmel\IscU
Associated Insertion(s)
Carried in Construct
P{IscU-S20A}
Key Links
Transgenic product class
missense_variant
(Tian et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Tian et al., 2014)
Mutagen
in vitro construct
(Tian et al., 2014)
Progenitor genotype
Carried in construct
P{IscU-S20A}
Cytology
Description

Genomic fragment containing a mutated form of IscU (has the amino acid replacement S20A).

(Tian et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
IscU
Encoded product / tool
IscU
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      IscU115 flies carrying IscUS20A are more sensitive to oxidative stress (either 10mM paraquat or 2% hydrogen peroxide) compared to controls.

      (Tian et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      IscUS20A partially rescues IscU115

      (Tian et al., 2014)
      Comments

      IscU115 homozygotes carrying IscUS20A are viable and have no visible morphological or developmental abnormalities.

      (Tian et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      IscUS20A
      Name Synonyms
      Secondary FlyBase IDs
        References (1)