FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\NavK1881A.UAS.mCherry
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General Information
Symbol
Dmel\NavK1881A.UAS.mCherry
Species
D. melanogaster
Name
FlyBase ID
FBal0301625
Feature type
allele
Associated gene
Dmel\Nav
Associated Insertion(s)
Carried in Construct
P{UAS-Nav-mCherry.K1881A}
Key Links
Transgenic product class
missense_variant
(Abe et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Abe et al., 2014)
Mutagen
in vitro construct
(Abe et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-Nav-mCherry.K1881A}
Cytology
Description

UAS regulatory sequences drive expression of a mutant form of sick, in which the lysine at amino acid 1881 has been replaced by alanine, tagged at the N-terminal end with mCherry.

(Abe et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Nav
Tagged with
mCherry
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of sickK1881A.Scer\UAS.T:Disc\RFP-mCherry does not suppress the axon growth defect and F-actin elevation seen in the α/β mushroom body lobes when LIMK1Scer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4ey-OK107.

      (Abe et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Scer\GAL4ey-OK107/NavK1881A.UAS.mCherry fails to rescue NavA384/NavΔ

      (Abe et al., 2014)

      Scer\GAL4NP7175/NavK1881A.UAS.mCherry fails to rescue NavA384/NavΔ

      (Abe et al., 2014)
      Comments

      Expression of sickK1881A.Scer\UAS.T:Disc\RFP-mCherry under the control of Scer\GAL4ey-OK107 fails to rescue the axonal growth defects seen in the α/β mushroom body lobes of sickΔ/sickA384 mutants.

      Expression of sickK1881A.Scer\UAS.T:Disc\RFP-mCherry under the control of Scer\GAL4NP7175 fails to rescue the axonal growth defects seen in the α/β mushroom body lobes of sickΔ/sickA384 mutants.

      (Abe et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      NavK1881A.UAS.mCherry
      sickK1881A.Scer\UAS.T:Disc\RFP-mCherry
      sickK1881A.UAS.mCherry
      Name Synonyms
      Secondary FlyBase IDs
        References (1)