FB2026_03 , released September 17, 2026
Allele: Hsap\HRH2TCS-GAL4.Tub.Tango
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General Information
Symbol
Hsap\HRH2TCS-GAL4.Tub.Tango
Species
H. sapiens
Name
FlyBase ID
FBal0301877
Feature type
allele
Associated gene
Hsap\HRH2
Associated Insertion(s)
Carried in Construct
P{Tub-HRH2-TCS-GAL4.Tango}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Jagadish et al., 2014)
Progenitor genotype
Carried in construct
P{Tub-HRH2-TCS-GAL4.Tango}
Cytology
Description

An α-tubulin promoter drives expression of a fusion protein which consists of Hsap\HRH2 fused at its C-terminus to Scer\GAL4, with the two coding sequences interposed by a TEV protease cleavage site (Tag:CS(TEVp)). The presence of Hsap\HRH2 (a G protein-coupled receptor) tethers the fusion protein to the cell membrane. The GAL4 driver can be released from the membrane by cleavage of the Tag:CS(TEVp) site with the TEVp protease.

(Jagadish et al., 2014)
Allele components
Component
Use(s)
Encoded product / tool
Hsap\HRH2
Tagged with
GAL4
Tag:CS(TEVp)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      lamina monopolar neuron | intense
      (Jagadish et al., 2014)
      adult optic lobe glial cell
      (Jagadish et al., 2014)
      adult ventral nerve cord | restricted
      (Jagadish et al., 2014)
      adult brain | restricted
      (Jagadish et al., 2014)
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\HRH2TCS-GAL4.Tub.Tango
      Hsap\HRH2Tub.Tango.T:Scer\GAL4
      Name Synonyms
      Secondary FlyBase IDs
        References (1)