FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mir-1017KO
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General Information
Symbol
Dmel\mir-1017KO
Species
D. melanogaster
Name
FlyBase ID
FBal0301899
Feature type
allele
Associated gene
Dmel\mir-1017
Associated Insertion(s)
TI{TI}mir-1017KO
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Chen et al., 2014)
Mutagen
ends-out gene targeting
(Chen et al., 2014)
FLPase
(Chen et al., 2014)
I-SceI
(Chen et al., 2014)
cre recombinase
(Chen et al., 2014)
Progenitor genotype
Associated Insertion(s)
TI{TI}mir-1017KO
Cytology
Description

The nAChRα2 host intron that normally includes mir-1017 is constitutively retained in TI{TI}mir-1017KO flies (a single loxP site replaces part of mir-1017 in these flies). Retention of the intron results in a premature stop codon that is predicted to truncate the nAChRα2 protein.

(Khanal et al., 2024)

The 8bp miRNA seed sequence of the mir-1017 miRtron has been deleted. A single loxP site is present at the site of the deletion. The expression of the nAChRα2 host gene appears unaffected (assayed by quantitative PCR).

(Chen et al., 2014)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      miR-1017 KO
      (Iftikhar et al., 2019)
      mir-1017KO
      (Khanal et al., 2024, Niu et al., 2019)
      mir-1017Δ
      (Khanal et al., 2024)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)