FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ScrΔKMAS.UAS
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General Information
Symbol
Dmel\ScrΔKMAS.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0301967
Feature type
allele
Associated gene
Dmel\Scr
Associated Insertion(s)
Carried in Construct
P{UAS-Scr.ΔKMAS}
Key Links
Transgenic product class
missense_variant
(Percival-Smith et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Percival-Smith et al., 2013)
Mutagen
in vitro construct
(Percival-Smith et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-Scr.ΔKMAS}
Cytology
Description

UAS regulatory sequences drive expression of a mutant form of Scr in which residues 384-387 (KMAS) have been replaced by alanines.

(Percival-Smith et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Scr
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of ScrΔKMAS.Scer\UAS under the control of Scer\GAL4rn.PU results in induction of ectopic sex combs on the second leg.

      Expression of ScrΔKMAS.Scer\UAS under the control of Scer\GAL4arm.PU results in ectopic T1 beards. Ectopic tarsi are seen when ScrΔKMAS.Scer\UAS is expressed under the control of Scer\GAL4dpp.PU.

      (Percival-Smith et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of ScrΔKMAS.Scer\UAS and pbScer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4pb.PJ results in a mild transformation of the antenna to proboscis, but this is not significantly different from controls.

      (Percival-Smith et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ScrΔKMAS.Scer\UAS
      ScrΔKMAS.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)