FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Scamp63A
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General Information
Symbol
Dmel\Scamp63A
Species
D. melanogaster
Name
FlyBase ID
FBal0302105
Feature type
allele
Associated gene
Dmel\Scamp
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Zheng et al., 2014)
Mutagen
Delta2-3 transposase
(Zheng et al., 2014)
Progenitor genotype
P{GSV1}GS1041
(Zheng et al., 2014)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in deletion of the 5' end of Scamp.

(Zheng et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous have no apparent morphological abnormalities, but males and females show a substantially reduced lifespan compared to controls. Scamp63A/Y males climb significantly slower than controls at 5-8 days after eclosion. Scamp63A/Scamp[50B] females climb significantly slower than controls and this declines with age.

      Scamp63A/Y males and Scamp63A/Scamp[50B] females show normal sensing and odor avoidance movements, but show significant impairment in long-term olfactory-associated memory formation.

      Scamp63A/Y males show greater susceptibility to heat-induced seizures than controls.

      (Zheng et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Scer\GAL4elav-C155-mediated expression of Hsap\SCAMP1Scer\UAS.T:Hsap\MYC or Hsap\SCAMP5Scer\UAS.T:Hsap\MYC substantially rescues the Scamp63A/Y climbing phenotype.

      Scer\GAL4elav-C155-mediated expression of Hsap\SCAMP1Scer\UAS.T:Hsap\MYC but not Hsap\SCAMP5Scer\UAS.T:Hsap\MYC rescues the long-term memory defect of Scamp63A/Y males.

      (Zheng et al., 2014)
      Complementation and Rescue Data
      Rescued by

      Scamp63A is rescued by Scer\GAL4elav-C155/ScampUAS.Tag:MYC

      (Zheng et al., 2014)
      Partially rescued by

      Scamp63A is partially rescued by Scer\GAL4elav-C155/ScampUAS.Tag:MYC

      (Zheng et al., 2014)
      Comments

      Scer\GAL4elav-C155-mediated expression of ScampScer\UAS.T:Hsap\MYC almost fully rescues the climbing phenotype and significantly improves the long-term memory defect of Scamp63A/Y males.

      Scer\GAL4elav-C155-mediated expression of ScampScer\UAS.T:Hsap\MYC partially rescues the heat-induced seizure phenotype of Scamp63A/Y males.

      (Zheng et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Scamp63A
      (Zheng et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)