FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ND-42SD.UAS
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General Information
Symbol
Dmel\ND-42SD.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0302208
Feature type
allele
Associated gene
Dmel\ND-42
Associated Insertion(s)
Carried in Construct
PBac{UAS-ND-42.SD}
Key Links
Transgenic product class
missense_variant
(Morais et al., 2014)
polypeptide_post_translational_processing_variant
(Morais et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Morais et al., 2014)
polypeptide_post_translational_processing_variant
(Morais et al., 2014)
Mutagen
in vitro construct
(Morais et al., 2014)
Progenitor genotype
Carried in construct
PBac{UAS-ND-42.SD}
Cytology
Description

UAS regulatory sequences drive expression of a phosphomimetic form of ND-42.

(Morais et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
ND-42
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Pink1B9
      (Morais et al., 2014, Pogson et al., 2014)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4da.PU/ND-42SD.UAS is a non-suppressor of abnormal flight phenotype of Pink1B9

      (Morais et al., 2014)
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of ND-42SD.Scer\UAS under the control of Scer\GAL4da.PU rescues the defects in NMJ neurotransmitter release seen in Pink1B9 mutant flies. Basal neurotransmitter release is unaffected in these flies. The defect in reserve pool vesicle loading is also rescued, as are the decrease in mitochondrial membrane potential at NMJ boutons and decreased ATP content. However, expression of ND-42SD.Scer\UAS does not rescue the severe flight muscle degeneration and flight defects seen in Pink1B9 mutant flies. Cristae structural organisation is improved without rescuing overall mitochondrial morphology.

      (Morais et al., 2014)

      Ubiquitous expression of ND-42SD.Scer\UAS under the control of Scer\GAL4da.PU partially rescues the climbing and flight defects seen in Pink1B9 mutant flies.

      Expression of ND-42SD.Scer\UAS under the control of Scer\GAL4da.PU rescues the reduction in complex I seen in Pink1B9 mutant flies.

      (Pogson et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ND-42SD.Scer\UAS
      ND-42SD.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)