FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\NAT1GS2099
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General Information
Symbol
Dmel\NAT1GS2099
Species
D. melanogaster
Name
FlyBase ID
FBal0302231
Feature type
allele
Associated gene
Dmel\NAT1
Associated Insertion(s)
P{GSV1}GS2099
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Yoshikane et al., 2007)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GSV1}GS2099
    Cytology
    Description

    Insertion in exon 3 (coding region) resulting in the truncation of the NAT1 protein just after amino acid 850 and deletion of almost the entire W2 domain.

    (Yoshikane et al., 2007)
    Allele components
    Component
    Use(s)
    Inserted element
    P{GSV1}
    Regulatory region(s)
    UASt
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        NAT1GS2099 embryos begin germband extension at approximately the correct time, but extension stops abruptly and the germband retracts. Mutants also exhibit an abnormally deep cephalic furrow. Mutants are able to form an embryonic cuticle, though they show a reduction in ventral cuticle bands.

        (Yoshikane et al., 2007)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        NAT1GS2099 is rescued by NAT1+t12.6

        (Yoshikane et al., 2007)
        Comments

        NAT1+t12.6 completely rescues the lethality associated with NAT1GS2099.

        (Yoshikane et al., 2007)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        NAT1GS2099
        dNAT1GS1
        (Yoshikane et al., 2007)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)