FlyBase Allele Report: Dmel\Tbcd[RNAi.UAS.cOa]

General Information

Symbol

Dmel\Tbcd^RNAi.UAS.cOa

Species

D. melanogaster

Name

FlyBase ID

FBal0302635

Feature type

allele

Associated gene

Dmel\Tbcd

Associated Insertion(s)

Carried in Construct

P{UAS-Tbcd.RNAi.O}

Key Links

Transgenic product class

RNAi_reagent

(Okumura et al., 2015)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Okumura et al., 2015)

Mutagen

in vitro construct

(Okumura et al., 2015)

Progenitor genotype

Carried in construct

P{UAS-Tbcd.RNAi.O}

Cytology

Description

UAS regulatory sequences drive expression of a transcript encoding two copies of mir-6-1 modified to target the TBCD 5' untranslated region. The target sequence is 5'-TGCAGTGGCTGCTATTTTAAAG-3'

(Okumura et al., 2015)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Tbcd

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^ey-OK107

(Okumura et al., 2015)

Phenotype Manifest In

adult mushroom body alpha-lobe, with Scer\GAL4^ey-OK107

(Okumura et al., 2015)

adult mushroom body beta-lobe, with Scer\GAL4^ey-OK107

(Okumura et al., 2015)

Detailed Description

Statement

Reference

Expression of TBCD^{miRNA.Scer\UAS} in all mushroom body neurons under the control of Scer\GAL4^ey-OK107 causes a loss of the β lobe and a thickened α-lobe.

(Okumura et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Tbcd^RNAi.UAS.cOa, Scer\GAL4^ey-OK107 is a suppressor of abnormal neuroanatomy phenotype of Dscam1^{exon17.2.UAS.GFP}, Scer\GAL4^ey-OK107

(Okumura et al., 2015)

Other

Statement

Reference

Scer\GAL4^GH146, Tbcb¹, Tbcd^RNAi.UAS.cOa has cell lethal | somatic clone | cell autonomous phenotype

(Okumura et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

Tbcd^RNAi.UAS.cOa, Scer\GAL4^ey-OK107 is a suppressor of adult mushroom body alpha-lobe phenotype of Dscam1^{exon17.2.UAS.GFP}, Scer\GAL4^ey-OK107

(Okumura et al., 2015)

Tbcd^RNAi.UAS.cOa, Scer\GAL4^ey-OK107 is a suppressor of adult mushroom body beta-lobe phenotype of Dscam1^{exon17.2.UAS.GFP}, Scer\GAL4^ey-OK107

(Okumura et al., 2015)

Other

Statement

Reference

Scer\GAL4^GH146, Tbcb¹, Tbcd^RNAi.UAS.cOa has adult antennal lobe projection neuron DL1 adPN | somatic clone | cell autonomous phenotype

(Okumura et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Very few single-cell clones are obtained when TBCD^{miRNA.Scer\UAS} is expressed in TBCB¹ mutant DL1 olfactory projection neuron clones under the control of Scer\GAL4^GH146.

Expression of TBCD^{miRNA.Scer\UAS} partially suppresses the loss of mushroom body α and β lobes seen in flies expressing Dscam1^{exon17.2.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^ey-OK107.

(Okumura et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

TBCD^{miRNA.Scer\UAS}

TBCD^miRNA.UAS

Tbcd^RNAi.UAS.cOa

Tbcd^miRNA.UAS

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

Open Close