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General Information
Symbol
Dmel\Lip4UAS.cLa
Species
D. melanogaster
Name
FlyBase ID
FBal0302645
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Lip4
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of Lip4 coding sequences (corresponding to cDNA clone RE12242).

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Expression of Lip4Scer\UAS.cLa under the control of Scer\GAL4ninaE.PT fails to rescue the neurodegeneration and electrophysiology defect seen in fh1 mutant photoreceptor clones.

Expression of Lip4Scer\UAS.cLa in sicilyE mutant clones partially restores the shape, density and number of identifiable rhabdomeres, indicating that reducing lipid droplet accumulation partially alleviates neurodegeneration.

Expression of Lip4Scer\UAS.cLa in Aats-metFB mutant clones partially restores the shape, density and number of identifiable rhabdomeres, indicating that reducing lipid droplet accumulation partially alleviates neurodegeneration.

Expression of Lip4Scer\UAS.cLa in MarfB mutant clones partially restores the shape, density and number of identifiable rhabdomeres, indicating that reducing lipid droplet accumulation partially alleviates neurodegeneration.

Neuronal expression of Lip4Scer\UAS.cLa (under the control of Scer\GAL4elav.PU) suppresses lipid droplet accumulation in MarfGD11094-knockdown glia.

Neuronal expression of Lip4Scer\UAS.cLa (under the control of Scer\GAL4elav.PU) suppresses lipid droplet accumulation in MarfGD11094-knockdown glia.

Neuronal expression of Lip4Scer\UAS.cLa (under the control of Scer\GAL4elav.PU) suppresses lipid droplet accumulation in Aats-metKK108492-knockdown glia.

Neuronal expression of Lip4Scer\UAS.cLa (under the control of Scer\GAL4elav.PU) suppresses lipid droplet accumulation in ND-42GD6220-knockdown glia.

Knockdown of Marf in neurons (MarfninaE.GD11094) and overexpression of Lip4Scer\UAS.cLa in glia (under the control of Scer\GAL454C) lowers lipid droplet accumulation and delays neurodegeneration.

Knockdown of ND-42 in neurons (ND-42ninaE.GD6220) and overexpression of Lip4Scer\UAS.cLa in glia (under the control of Scer\GAL454C) lowers lipid droplet accumulation and peroxidation and delays neurodegeneration.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Lip4Scer\UAS.cLa
Lip4UAS.cLa
Name Synonyms
Secondary FlyBase IDs
    References (3)