FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\S6KLUAS.cZa
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General Information
Symbol
Dmel\S6KLUAS.cZa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Zhao
FlyBase ID
FBal0302975
Feature type
allele
Associated gene
Dmel\S6KL
Associated Insertion(s)
Carried in Construct
P{UAS-S6KL.Z}
Key Links
Transgenic product class
wild_type
(Zhao et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Zhao et al., 2015)
Mutagen
in vitro construct
(Zhao et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-S6KL.Z}
Cytology
Description

UASt regulatory sequences drive expression of full length S6KL.

(Zhao et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
S6KL
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pre-synaptic expression of S6KLScer\UAS.cZa under the control of Scer\GAL4elav.PU results in a significant decrease in the number of total boutons in the neuromuscular junction compared to controls. Satellite bouton number is similar to controls. Postsynaptic expression under the control of Scer\GAL4C57 has no effect on bouton number.

      (Zhao et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav.PU/S6KLUAS.cZa rescues S6KL140

      (Zhao et al., 2015)
      Fails to rescue

      Scer\GAL4Mhc.PU/S6KLUAS.cZa fails to rescue S6KL140

      (Zhao et al., 2015)
      Comments

      Pre-synaptic expression of S6KLScer\UAS.cZa under the control of Scer\GAL4elav.PU fully rescues the neuromuscular junction overgrowth phenotype seen in homozygous S6KL140 mutants. The increase in quantal content seen in S6KL140 mutant flies is also rescued.

      Post-synaptic expression of S6KLScer\UAS.cZa under the control of Scer\GAL4Mhc.PU does not rescue the neuromuscular junction overgrowth phenotype seen in homozygous S6KL140 mutants.

      (Zhao et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      S6KLScer\UAS.cZa
      S6KLUAS.cZa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Zhao
      Secondary FlyBase IDs
        References (1)