FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ctr1CUAS.cSa
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General Information
Symbol
Dmel\Ctr1CUAS.cSa
Species
D. melanogaster
Name
FlyBase ID
FBal0303932
Feature type
allele
Associated gene
Dmel\Ctr1C
Associated Insertion(s)
Carried in Construct
P{UAS-Ctr1C.S}
Key Links
Transgenic product class
wild_type
(Steiger et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Steiger et al., 2010)
Mutagen
in vitro construct
(Steiger et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Ctr1C.S}
Cytology
Description

UAS regulatory sequences drive expression of Ctr1C sequences corresponding to Ctr1C-PA (FBpp0085111).

(Steiger et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Ctr1C
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Strong ubiquitous expression of Ctr1CScer\UAS.cSa under the control of Scer\GAL4Act5C.PU is lethal when the flies are raised on normal food. such flies can be rescued by growing them on food supplemented with the copper chelator BCS.

      Strong, eye-specific expression of Ctr1CScer\UAS.cSa (through the P{UAS-Ctr1C.S}C34 insertion) under the control of Scer\GAL4GMR.PF leads to severely disrupted eye morphology (the rigid quasi-crystalline pattern of the ommatidia is lost and ommatidia are fused, leading to an uneven eye surface; in addition, overall eye shape is changed) when raised on normal food. This rough eye phenotype can be fully rescued by the addition of the copper chelator BCS. A weaker transgene insertion (P{UAS-Ctr1C.S}D22) does not alter eye morphology on normal food but causes a strong rough eye phenotype on food containing elevated levels of copper.

      (Steiger et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Scer\GAL4Tub.PU/Ctr1CUAS.cSa is a suppressor of lethal phenotype of Ctr1A25

      (Steiger et al., 2010)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Ctr1CScer\UAS.cSa under the control of Scer\GAL4tub.PU can fully suppress the lethality found in Ctr1A25 mutants.

      (Steiger et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ctr1CScer\UAS.cSa
      Ctr1CUAS.cSa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)