FB2026_02 , released June 18, 2026
Allele: Dmel\Ctr1C6D
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General Information
Symbol
Dmel\Ctr1C6D
Species
D. melanogaster
Name
FlyBase ID
FBal0303936
Feature type
allele
Associated gene
Dmel\Ctr1C
Associated Insertion(s)
TI{EGFP}Ctr1C6D
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ends-in gene targeting
(Steiger et al., 2010)
Progenitor genotype
Associated Insertion(s)
TI{EGFP}Ctr1C6D
Cytology
Description

Sequence encoding amino acids 1-13 of Ctr1C have been replaced with the EGFP open reading frame followed by an SV40 polyA sequence and several stop codons. This allows expression of EGFP under the control of Ctr1C regulatory sequences. Expression of the residual Ctr1C ORF is unlikely due to the presence of the SV40 polyA sequence and the stop codons.

(Steiger et al., 2010)
Allele components
Component
Use(s)
Inserted element
TI{EGFP}
Encoded product / tool
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ctr1C6D mutants do not show reduced fertility compared with wild-type controls.

      Ctr1C6D homozygotes does not show sensitivity to either elevated or reduced copper levels in food.

      (Steiger et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Ctr1B3-4, Ctr1C6D has male semi-sterile phenotype, suppressible by Ctr1CEGFP

      (Steiger et al., 2010)

      Ctr1B3-4, Ctr1C6D has male semi-sterile phenotype, suppressible by Ctr1C+t8

      (Steiger et al., 2010)

      Ctr1B3-4, Ctr1C6D has male semi-sterile phenotype, suppressible by Ctr1BGFP

      (Steiger et al., 2010)
      Suppressor of
      Statement
      Reference

      Ctr1C6D is a suppressor of male fertile phenotype of Ctr1B3-4

      (Steiger et al., 2010)
      Other
      Statement
      Reference

      Ctr1B3-4, Ctr1C6D has male semi-sterile phenotype

      (Steiger et al., 2010)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Although 12 day old mutant Ctr1B3-4 males are fertile, Ctr1B3-4 Ctr1C6D double mutant males display almost complete sterility, indicating that in the absence of Ctr1B, Ctr1C is required for male fertility. These males are only partially sterile before this time however. Testes at any age do not reveal obvious morphological differences compared to control males. If Ctr1B3-4 Ctr1C6D double mutant males are kept on food supplemented with copper after eclosion, i.e. as adult flies, for 12 days, fertility is largely restored. Fertility is also restored by the presence of Ctr1CT:Avic\GFP-EGFP, Ctr1C+t8 or Ctr1BT:Avic\GFP.

      (Steiger et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Fertility in Ctr1B3-4 Ctr1C6D double mutant males is restored by the presence of Ctr1CT:Avic\GFP-EGFP or Ctr1C+t8.

      Fertility in Ctr1B3-4 Ctr1C6D double mutant males is restored by the presence of Ctr1BT:Avic\GFP.

      (Steiger et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ctr1C6D
      (Steiger et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)