FlyBase Allele Report: Dmel\Hr39[C105]

General Information

Symbol

Dmel\Hr39^C105

Species

D. melanogaster

Name

FlyBase ID

FBal0304303

Feature type

allele

Associated gene

Dmel\Hr39

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Boulanger et al., 2011)

Progenitor genotype

Hr39^GS9939

(Boulanger et al., 2011)

Cytology

Description

Imprecise excision of P{GSV6}Hr39^GS9939 generates a ~8kb deletion of genomic DNA starting 7.4kb upstream of the ATG and removing 520bp of the coding sequence.

(Boulanger et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Boulanger et al., 2011)

viable

(Boulanger et al., 2011)

Phenotype Manifest In

alpha/beta Kenyon cell

(Boulanger et al., 2011)

Detailed Description

Statement

Reference

Hr39^C105 flies show normal γ axon pruning but exhibit αβ axon defects, such as axon defasciculation and α axon misguidance.

(Boulanger et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Hr39^C105 is a non-enhancer of abnormal neuroanatomy phenotype of usp^unspecified

(Boulanger et al., 2011)

NOT Suppressor of

Statement

Reference

Hr39^C105 is a non-suppressor of abnormal neuroanatomy phenotype of usp^unspecified

(Boulanger et al., 2011)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Hr39^C105, usp^unspecified has gamma Kenyon cell phenotype, non-enhanceable by ftz-f1^β.UAS.cBa/Scer\GAL4^Tab2-201Y

(Boulanger et al., 2011)

NOT suppressed by

Statement

Reference

Hr39^C105, usp^unspecified has gamma Kenyon cell phenotype, non-suppressible by ftz-f1^β.UAS.cBa/Scer\GAL4^Tab2-201Y

(Boulanger et al., 2011)

NOT Enhancer of

Statement

Reference

Hr39^C105 is a non-enhancer of gamma Kenyon cell phenotype of usp^unspecified

(Boulanger et al., 2011)

NOT Suppressor of

Statement

Reference

Hr39^C105 is a non-suppressor of gamma Kenyon cell phenotype of usp^unspecified

(Boulanger et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

usp^unspecified Hr39^C105 double mutants exhibit a severe neuronal pruning phenotype.

Expression of ftz-f1^{β.Scer\UAS.cBa} in usp^unspecified Hr39^C105 double mutant neuroblast clones does not suppress the severe neuronal pruning phenotype observed in these mutants.

(Boulanger et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

64285