FB2026_02 , released June 18, 2026
Allele: Dmel\Nap1KO1
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General Information
Symbol
Dmel\Nap1KO1
Species
D. melanogaster
Name
FlyBase ID
FBal0304371
Feature type
allele
Associated gene
Dmel\Nap1
Associated Insertion(s)
TI{TI}Nap1KO1
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ends-in gene targeting
(Lankenau et al., 2003)
FLPase
(Lankenau et al., 2003)
I-SceI
(Lankenau et al., 2003)
recombination
(Lankenau et al., 2003)
Progenitor genotype
Associated Insertion(s)
TI{TI}Nap1KO1
Cytology
Description

Duplication of the Nap1 gene, with each copy containing a frameshift mutation, so that both should be non-functional. A w+mW.hs marker is present between the two copies.

(Lankenau et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant males do not have mature sperm in the seminal vesicle. During individualisation, actin cap formation is not seen and the nuclear bundles are disrupted.

      Dp(3;3)Nap1KO1 males do not have mature sperm in the seminal vesicle. During individualisation, actin cap formation is not seen and the nuclear bundles are disrupted.

      (Kimura, 2013)

      The hatch rate of Dp(3;3)Nap1KO1 flies is a factor of 5 lower than expected.

      The hatch rate of Dp(3;3)Nap1KO1 flies is a factor of 5 lower than expected.

      (Lankenau et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      Dp(3;3)Nap1KO1
      NAP1KO1
      (Doyen et al., 2015)
      Nap1KO1.3'
      Nap1KO1.5'
      Nap1KO1
      (Kimura, 2013, Lankenau et al., 2003)
      nap-1 K.O.
      (López-Panadès and Casacuberta, 2016)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0147747
      • FBal0147746
      • FBab0037611
      References (5)