FB2026_03 , released September 17, 2026
Allele: Dmel\tremH378Y
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General Information
Symbol
Dmel\tremH378Y
Species
D. melanogaster
Name
FlyBase ID
FBal0304602
Feature type
allele
Associated gene
Dmel\trem
Associated Insertion(s)
Carried in Construct
P{trem.H378Y}
Key Links
Transgenic product class
missense_variant
(Lake et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Lake et al., 2011)
Mutagen
in vitro construct
(Lake et al., 2011)
Progenitor genotype
Carried in construct
P{trem.H378Y}
Cytology
Description

A 2.5kb genomic construct containing a mutant form of the trem gene region in which the histidine at amino acid 378 has been replaced with tyrosine (H378Y).

(Lake et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
trem
Encoded product / tool
trem
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      tremH378Y fails to rescue tremf05981

      (Lake et al., 2011)
      Comments

      Expression of tremH378Y does not rescue either the fertility or the meiotic defects observed in tremf05981 homozygotes.

      (Lake et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      tremH378Y
      Name Synonyms
      Secondary FlyBase IDs
        References (1)