Expression of mTerf3^{dsRNA.Scer\UAS.cUa} using Scer\GAL4^ey.PU results in a massive phenotype with reduced eye-size and disorganized head structure.

Ubiquitous expression of mTerf3^{dsRNA.Scer\UAS.cUa} under the control of Scer\GAL4^da.PU results in reduced larval body size. The knock-down larvae are visible smaller from 4 days after egg-laying (AEL) and onwards and show reduced body weight in comparison with controls. The knock-down larvae display development and eventually they die at the pupal stage.

Scer\GAL4^da.PU>mTerf3^{dsRNA.Scer\UAS.cUa} larvae at 3-6 days AEL show a major reduction in oxygen consumption rates compared with wild-type. An increase of mtDNA levels are also observed in the mutant larvae at 6 days AEL compared with controls. Scer\GAL4^da.PU>mTerf3^{dsRNA.Scer\UAS.cUa}-expression leads to reduced levels of mitochondrial ribosome assembly compared with wild-type.

Scer\GAL4^da.PU, mTerf3^RNAi.UAS.cUa has decreased body size | larval stage phenotype, suppressible by Dpse\Mterf3^+t10