FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\S-Lap2GD10864
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General Information
Symbol
Dmel\S-Lap2GD10864
Species
D. melanogaster
Name
FlyBase ID
FBal0305330
Feature type
allele
Associated gene
Dmel\S-Lap2
Associated Insertion(s)
Carried in Construct
P{GD10864}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Butzlaff et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Butzlaff et al., 2015)
Mutagen
in vitro construct
(Butzlaff et al., 2015)
Progenitor genotype
Carried in construct
P{GD10864}
Cytology
Description

UASt regulates expression of a dsRNA targeting S-Lap2 for RNAi-mediated degradation.

(Butzlaff et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD10864
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  tauopathy
      modeled by Hsap\MAPTR406W.UAS
      (Butzlaff et al., 2015)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults expressing S-Lap2GD10864 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhancer of
      Suppressor of
      Statement
      Reference

      S-Lap2GD10864, Scer\GAL4GMR.PF is a suppressor of eye phenotype of Hsap\MAPTR406W.UAS, Scer\GAL4GMR.PF

      (Butzlaff et al., 2015)
      NOT Suppressor of
      Statement
      Reference

      S-Lap2GD10864, Scer\GAL4GMR.PF is a non-suppressor of eye phenotype of Hsap\ATXN3tr.Q78.UAS.Tag:HA, Scer\GAL4GMR.PF

      (Butzlaff et al., 2015)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      S-Lap2GD10864
      Name Synonyms
      Secondary FlyBase IDs
        References (4)